Heterocyclic Compounds and Biological Applications

Gabriele Jovtchev, Bhattiprolu Kesava Rao, Sarbjit Singh, Koteswara Rao Valasani, Jalari Ramu  © by the authors

ISBN: 978-1-940366-76-0
Published Date: September, 2021
Paperback: $120
Publisher: Science Publishing Group
To purchase hard copies of this book, please email: book@sciencepublishinggroup.com
Book Description

This book differs from others on name reactions in organic chemistry by focusing on their mechanisms and biological applications like Anti Cancer, Anti HIV and antimicrobial and some more. It covers over number of classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles.

The book is very useful to the researchers, post graduates and UG students. A Text Book of Heterocyclic Compounds and Biological Applications shows readers how to interpret the experimental data obtained from an organic reaction, and specifically how an organic reaction mechanism can be considered or rejected based on the analysis of the experimental evidence. Examining a series of selected examples of mechanisms, organic reaction mechanisms and biological applications focus on real cases and discuss them in detail, following the same methodology: introduction, experimental data and discussion. The examples are arranged to elucidate key aspects of organic reaction mechanisms. The authors employ all the types of information that the authors of the original work considered useful and necessary, including kinetic and thermodynamic data, isotopic labeling and organic reactivity. The book makes an excellent primer for advanced researchers and post graduate and undergraduates in chemistry who are preparing for exams and is also useful for graduate students and instructors.

Author Introduction

Gabriele Jovtchev (Ph.D) is an Associate Professor in the Department of Ecosystem Research, Environmental Risk Assessment and Conservation Biology, Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences.

Bhattiprolu Kesava Rao (M.Sc., Ph.D.) is a Professor who works at Chairman-Board of Studies, Department of Chemistry, Acharya Nagarjuna University, India.

Sarbjit Singh (Ph.D.) currently works in the Department of Pharmacy, College of Pharmacy, Dongguk University, Republic of Korea.

Dr. Koteswara Rao Valasani currently works in the Department of Pharmacology & Toxicology and Higuchi Bioscience Center, School of Pharmacy, University of Kansas, USA.

Dr. Jalari Ramu is an Associate Professor of Biochemistry in School of Medicine, Debre Markos University, Ethiopia.

Table of Contents
  • The Whole Book

  • Front Matter

  • Chapter 1 Biological Activity of Novel Ureas and Thioureas Containing Bioactive Heterocycles

    1. 1.1 Introduction
    2. 1.2 Biological Activity of Novel Ureas and Thioureas Containing Bioactive Heterocycles
    3. 1.2.1 Series One: 1,1’-Hexamethylenebis(3-substituted)ureas
    4. 1.2.2 Series Two: N-aryl and alkyl-N’-(heterocycle)ureas and Thioureas
    5. 1.2.3 Series Three: 1-methyl and acetyl-4-substituted Piperazines
    6. 1.3 Conclusions
  • Chapter 2 Heterocyclic Compounds and Their Biological Applications of Semecarpus anacardium L.f

    1. 2.1 Introduction
    2. 2.2 Materials and Methods
    3. 2.2.1 Plant Material
    4. 2.2.2 Preparation of Plant Extract
    5. 2.3 Glycolipids
    6. 2.3.1 Column Chromatography and Thin-Layer Chromatography of Lipid Classes
    7. 2.3.2 Tocopherols
    8. 2.4 Heterocyclic Compounds from SA Flowers & Leaves
    9. 2.5 Isolation and Purification of Biflavonoids from SA Nuts, Leaves and Root Bark
    10. 2.6 Docking Studies
    11. 2.6.1 SCF in the Active Site of PtP1B
    12. 2.6.2 THAF in the Active Site of PtP1B
    13. 2.7 Antimicrobial Activity of the Isolated Compounds
    14. 2.8 Radical Scavenging Activity Using DPPH Method
    15. 2.9 Conclusion
  • Chapter 3 1,3,5-Triazine Based Compounds: Synthesis and Anti-Cancer Activities

    1. 3.1 Introduction
    2. 3.2 Synthesis and Anti-Cancer Actvities of 1,3,5-Triazine Derivative
    3. 3.3 Conclusion
  • Chapter 4 Neocarzinostatin - New Promises in Anticancer Activities

    1. 4.1 Introduction
    2. 4.2 Neocarzinostatin Chromophore
    3. 4.3 Enediyne Core of NCS Biosynthesis
    4. 4.4 Naphthoic Acid Biosynthesis
    5. 4.5 Deoxyamino Sugar Biosynthesis
    6. 4.6 Biosynthesis of NCS by Joining Together Peripheral Moieties to Enediyne Core
    7. 4.7 Mechanism of Action of NCSon Cancer Cel
    8. 4.8 Conclusion and Future Prospects
  • Chapter 5 Synthetic and Biological Applications of Benzothiazole Phosphonates

    1. 5.1 Introduction
    2. 5.2 Synthetic Pathways of Benzothiazole Phosphonates
    3. 5.2.1 Kabachnik-Fields Reaction
    4. 5.2.2 Mannich-Type Addition
    5. 5.2.3 Direct Phosphonylation of Benzothiazole
    6. 5.3 Biological Applications of Benzothiazole Phosphonates
    7. 5.3.1 Antitumor Activity
    8. 5.3.2 Antimicrobial Activity
    9. 5.3.3 Antioxidant Activity
    10. 5.3.4 Benzothiazole α-Aminophosphonate Derivatives for Treating Alzheimer’s Disease
    11. 5.4 Conclusions
  • Back Matter